Recent Papers (2014-2017). Click here for a full list and citation data.

Som NF, Heine D, Holmes N, Knowles F, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B* and Hutchings MI* (2017). The MtrAB two component system controls antibiotic production in Streptomyces coelicolor A3(2). Microbiology. doi: 10.1099/mic.0.000524. Abstract. GOLD Open Access. bioRxiv preprint.

Som NF, Heine D, Holmes N, Munnoch JT, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B* and Hutchings MI* (2017). The conserved actinobacterial two-component system MtrAB coordinates chloramphenicol production with sporulation in Streptomyces venezuelae NRRL B-65442. Frontiers Microbiol. 8:1145. Abstract. GOLD Open Access. bioRxiv preprint.

van der Meij A, Worsley SF, Hutchings MI and van Wezel GP (2017). Chemical ecology of antibiotic production by actinomycetes. FEMS Microbiol Rev. 41:392-416. Abstract.

Devine R, Hutchings MI* and Holmes NA* (2017). Future directions for the discovery of antibiotics from actinomycete bacteria. Emerging Topics in Life Sciences. 1:1-12. Abstract

Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE and Fontecilla-Camps JC (2017). Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. Nature Comms 8:15052. Abstract. GOLD Open Access

Qin Z, Munnoch, JT, Devine R, Holmes N, Seipke RF, Wilkinson B* and Hutchings MI* (2017). Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chem. Sci. 8: 3218-3227 Abstract. GOLD Open Access

Holmes NA, Innocent TM, Heine D, Al Bassam M, Worsley SF, Trottman F, Patrick EH, Yu DW, Murrell JC, Schiott M, WIlkinson B, Boomsma JJ and Hutchings MI (2016). Genome analysis of two Pseudonocardia phylotypes associated with Acromyrmex leafcutter ants reveals their biosynthetic potential. Frontiers Microbiol. 7:2-73. Abstract. GOLD Open Access.

Serrano PN, Wang H, Crack JC, Prior C, Hutchings MI, Thomson AJ, Kamali S, Yoda Y, Zhao J, Hu MY, Alp, EE, Oganesyan VS, Le Brun NE and Cramer SP (2016). Nitrosylation of Nitric Oxide-Sensing [4Fe-4S] Cluster Regulatory Proteins Results in a Mixture of Iron-Nitrosyl Products. Angewandte Chemie. 55:14575–14579. Abstract.

Munnoch JT, Pellicer-Martinez MT, Svistunenko DA, Crack JC, Le Brun NE* and Hutchings MI* (2016). Characterization of a putative NsrR homologue in Streptomyces venezuelae reveals a new member of the Rrf2 superfamily. Scientific Reports 6, 31597 . GOLD Open Access. Preprint available at bioRxiv

Crack JC, Svistunenko DA, Munnoch JT, Thomson AJ, Hutchings MI and Le Brun NE (2016). Differentiated, promoter-specific response of [4Fe-4S] NsrR DNA binding to reaction with nitric oxide. J Biol Chem. 291:8663-72. Abstract.

Munnoch JT, Widdick DA, Chandra G, Sutcliffe IC, Palmer T and Hutchings MI (2016). Cosmid based mutagenesis causes genetic instability in Streptomyces coelicolor, as shown by targeting of the lipoprotein signal peptidase gene. Scientific Reports 6:29495. GOLD Open Access. Preprint available at bioRxiv

Crack JC, Hutchings MI, Thomson A and Le Brun NE (2016). Biochemical properties of Paracoccus denitrificans FnrP: Reactions with molecular oxygen and nitric oxide. J Biol Inorg Chem. 21:71–82. Abstract

Crack JC, Munnoch JT, Dodd E, Knowles F, Al Bassam MM, Kamali S, Holland AA, Cramer SP, Hamilton C, Johnson MK, Thomson AJ, Hutchings MI* and Le Brun NE* (2015). NsrR from Streptomyces coelicolor is a nitric oxide sensing [4Fe-4S] cluster protein with specialized regulatory function. J Biol Chem. 290:12689-704. Abstract

Hutchings MI (2014). Nature's untapped antibiotic arsenal. CHEMISTRY & INDUSTRY. 78:18 Full text

Gao H., Grüschow S., Barke J., Seipke R.F., Hill L.M., Orivel J., Yu, D.W. Hutchings M. and Goss R.J.M (2014). Filipins: the first antifungal “weed killers” identified from bacteria isolated from the trap-ant. RSC Advances DOI: 10.1039/x0xx00000x. Abstract.

Seipke R.F., Patrick E. and Hutchings M.I (2014). Regulation of antimycin biosynthesis by the orphan ECF RNA polymerase sigma factor σAntA. Peer J. 2:e253 GOLD Open Access. This paper was also published as a Peer J Preprint