Papers and Preprints from 2017-2019. Click here for a full list and citation data.

Vikeli E, Widdick DA, Batey SF, Heine D, Holmes NA, Bibb MJ, Pierce N, Hutchings MI* and Wilkinson B* (2019). In situ activation and heterologous production of a cryptic lantibiotic from a plant-ant derived Saccharopolyspora species. Submitted. Preprint here.

Hutchings MI, Truman A and Wilkinson B (2019). Antibiotics: past, present and future. Curr Op Microbiol. Under review.

Worsley SF, Macy MC, Wilkinson B, Yu DW, Murrell JC and Hutchings MI (2019). Investigating the role of exudates in shaping the Arabidopsis thaliana root microbiome using DNA stable isotope probing. ISME J. Under review. Preprint here.

Qin Z#, Devine R#, Hutchings MI* and Wilkinson B* (2019). A role for ABM domain proteins in fidelity control during aromatic polyketide biosynthesis. Nature Comms 10:3611. Abstract. GOLD Open Access.

McLean T, Lo R, Tschowri N, Hoskisson PA, Al Bassam MM, Hutchings MI and Som N (2019). Sensing and responding to diverse extracellular signals: An updated analysis of the sensor kinases and response regulators of Streptomyces spp. Microbiology doi:10.1099/mic.0.000817.

McLean T, Wilkinson B, Hutchings MI and Devine R (2019). Dissolution of the disparate: co-ordinate regulation in antibiotic biosynthesis. Antibiotics. 8:83. Abstract. GOLD Open Access.

Newitt JT, Prudence SMM, Hutchings MI and Worsley SF (2019). Biocontrol of cereal crop diseases using streptomycetes. Pathogens. 8:78 Abstract. GOLD Open Access.

Tran NT, Huang X, Hong H-J, Bush MJ, Chandra G, Pinto D, Bibb MJ, Hutchings MI, Mascher T and Buttner MJ (2019). Defining the regulon of genes controlled by σE, a key regulator of the cell envelope stress response in Streptomyces coelicolor. Mol. Microbiol. https://doi.org/10.1111/mmi.14250.

Volbeda A., Pellicer Martinez MT, Crack JC, Gigarel O, Munnoch JT, Hutchings MI, Darnault C, Le Brun NE, Fontecilla-Camps JC (2019). The Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu and His Residues. J Am Chem Soc 141:2367-75.

Innocent T, Holmes NA, Al Bassam M, Schiott M, Scheuring I, Wilkinson B, Hutchings MI, Boomsma JJ, and Yu DW (2018). Experimental demonstration that screening can enable the environmental recruitment of a defensive microbiome. bioRxiv doi: https://doi.org/10.1101/375634

Leftwich P, Hutchings MI and Chapman T (2018). Diet, Microbes and Host Mate Choice. Bioessays. 40:1800053. Abstract. GOLD Open Access.

Worsley SF, Innocent TM, Heine D, Murrell JC, Yu DW, Wilkinson B, Hutchings MI, Boomsma JJ and Holmes NA (2018). Symbiotic Partnerships and their Chemical Interactions in the Leafcutter Ants (Hymenoptera: Formicidae). Myrmecological News. 27:59-74. GOLD Open Access. Abstract

Heine D#, Holmes NA#, Worsley SF, Alve dos Santos AC, Innocent TM, Scherlach K, Patrick E, Yu DW, Murrell JC, Boomsma JJ, Hertweck C, Hutchings MI* and Wilkinson B* (2018). Chemical warfare between leafcutter ant symbionts and a co-evolved pathogen. Nature Comms. 9:2208. GOLD Open Access. Abstract

Holmes NA, Devine R, Qin Z, Seipke RF, Wilkinson B, Hutchings MI (2018). Complete genome sequence of Streptomyces formicae KY5, the formicamycin producer. J Biotech. 265:116-8. Abstract

Leftwich PT, Clarke NVE, Hutchings MI and Chapman T (2017). Gut Microbiomes and reproductive isolation in Drosophila. Proc Natl Acad Sci USA. 114:12767-12772. Abstract. This paper led to a number of letters to PNAS and our responses were published by the journal:

  • Reply to Rosenberg et al: Diet, gut bacteria, and assortative mating in Drosophila melanogaster. Leftwich PT, Clarke NVE, Hutchings MI and Chapman T (2018). Proc Natl Acad Sci USA. 115: E2154-E2155 Full text
  • Reply to Obadia et al: Effect of methyl paraben on host-microbiota interactions in Drosophila melanogaster. Leftwich PT, Clarke NVE, Hutchings MI and Chapman T (2018). Proc Natl Acad Sci USA. 115:E4549-E4550. Full text

Som NF, Heine D, Holmes N, Knowles F, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B* and Hutchings MI* (2017). The MtrAB two component system controls antibiotic production in Streptomyces coelicolor A3(2). Microbiology. 163: 1415-1419. Abstract. GOLD Open Access. bioRxiv preprint.

Som NF, Heine D, Holmes N, Munnoch JT, Chandra G, Seipke RF, Hoskisson PA, Wilkinson B* and Hutchings MI* (2017). The conserved actinobacterial two-component system MtrAB coordinates chloramphenicol production with sporulation in Streptomyces venezuelae NRRL B-65442. Frontiers Microbiol. 8:1145. Abstract. GOLD Open Access. bioRxiv preprint.

van der Meij A, Worsley SF, Hutchings MI and van Wezel GP (2017). Chemical ecology of antibiotic production by actinomycetes. FEMS Microbiol Rev. 41:392-416. Abstract.

Devine R, Hutchings MI* and Holmes NA* (2017). Future directions for the discovery of antibiotics from actinomycete bacteria. Emerging Topics in Life Sciences. 1:1-12. Abstract

Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE and Fontecilla-Camps JC (2017). Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding. Nature Comms 8:15052. Abstract. GOLD Open Access

Qin Z, Munnoch, JT, Devine R, Holmes N, Seipke RF, Wilkinson B* and Hutchings MI* (2017). Formicamycins, antibacterial polyketides produced by Streptomyces formicae isolated from African Tetraponera plant-ants. Chem. Sci. 8: 3218-3227 Abstract. GOLD Open Access